Cancers, Free Full-Text
Por um escritor misterioso
Last updated 15 março 2025

Ubiquitin-like, containing PHD and RING finger domain, (UHRF) family members are overexpressed putative oncogenes in several cancer types. We evaluated the protein abundance of UHRF family members in acute leukemia. A marked overexpression of UHRF1 protein was observed in ALL compared with AML. An analysis of human leukemia transcriptomic datasets revealed concordant overexpression of UHRF1 in B-Cell and T-Cell ALL compared with CLL, AML, and CML. In-vitro studies demonstrated reduced cell viability with siRNA-mediated knockdown of UHRF1 in both B-ALL and T-ALL, associated with reduced c-Myc protein expression. Mechanistic studies indicated that UHRF1 directly interacts with c-Myc, enabling ALL expansion via the CDK4/6-phosphoRb axis. Our findings highlight a previously unknown role of UHRF1 in regulating c-Myc protein expression and implicate UHRF1 as a potential therapeutic target in ALL.
27+ Cancer Pictures Download Free Images & Stock Photos on Unsplash
The cancer journals : Audre Lorde : Free Download, Borrow, and

Home - Free ME from Lung Cancer

Cancer
National Comprehensive Cancer Network - Home

Remission, cancer-free, no evidence of disease: What's the

ONE year and Cancer FREE!

Frailty and prognosis in lung cancer: systematic review and meta
Recomendado para você
-
Gorro Cirúrgico, IGG+ Positivo, Rosa Neon, Fundo Preto - ToucaTop - Toucas Cirúrgicas Divertidas e Personalizadas15 março 2025
-
Immuno Gold Rabbit-anti-Chicken, IgG15 março 2025
-
Vidiverse15 março 2025
-
igg games (@igggames2) / X15 março 2025
-
A+Z15 março 2025
-
Cute Immunology Lanyard Immune Cells Antibodies Science15 março 2025
-
A Girl with a Bright Red Manicure Holds a Coronavirus Test and a Lancet for a Blood Test in Her Hand. Determination of IgG and IgM Stock Photo - Image of girl15 março 2025
-
Frontiers EBV Exploits RNA m6A Modification to Promote Cell Survival and Progeny Virus Production During Lytic Cycle15 março 2025
-
Immobilization of the IgG and Prostate Specific Antigen (PSA) on SU-815 março 2025
-
Be Notorious Individual Graduation Greeting Cards by Laura Bolter15 março 2025
você pode gostar
-
ITALIAN, 19TH CENTURY, AFTER THE ANTIQUE15 março 2025
-
Estou cansada de sombras, disse a Senhora de Shalott - Wikiwand15 março 2025
-
Gallery: Take a Close Look At All The Latest Pokémon and Features15 março 2025
-
Girl group ITZY to drop new EP 'Checkmate15 março 2025
-
Exclusive Sonic Mania Adventures Tails Poster15 março 2025
-
Inuyashiki Anime, Desenhos chineses, Desenho15 março 2025
-
Papers Please Remastered15 março 2025
-
Regarding Copyright15 março 2025
-
FINAL APOCALYPSE: O REQUIEM DAS SOMBRAS - 9786587068107 - Livros15 março 2025
-
Qual Hashira de Kimetsu no Yaiba você seria?, Quizur15 março 2025