Cancers, Free Full-Text

Por um escritor misterioso
Last updated 15 março 2025
Cancers, Free Full-Text
Ubiquitin-like, containing PHD and RING finger domain, (UHRF) family members are overexpressed putative oncogenes in several cancer types. We evaluated the protein abundance of UHRF family members in acute leukemia. A marked overexpression of UHRF1 protein was observed in ALL compared with AML. An analysis of human leukemia transcriptomic datasets revealed concordant overexpression of UHRF1 in B-Cell and T-Cell ALL compared with CLL, AML, and CML. In-vitro studies demonstrated reduced cell viability with siRNA-mediated knockdown of UHRF1 in both B-ALL and T-ALL, associated with reduced c-Myc protein expression. Mechanistic studies indicated that UHRF1 directly interacts with c-Myc, enabling ALL expansion via the CDK4/6-phosphoRb axis. Our findings highlight a previously unknown role of UHRF1 in regulating c-Myc protein expression and implicate UHRF1 as a potential therapeutic target in ALL.
Cancers, Free Full-Text
27+ Cancer Pictures Download Free Images & Stock Photos on Unsplash
Cancers, Free Full-Text
The cancer journals : Audre Lorde : Free Download, Borrow, and
Cancers, Free Full-Text
Home - Free ME from Lung Cancer
Cancers, Free Full-Text
Cancer
Cancers, Free Full-Text
National Comprehensive Cancer Network - Home
Cancers, Free Full-Text
Remission, cancer-free, no evidence of disease: What's the
Cancers, Free Full-Text
ONE year and Cancer FREE!
Cancers, Free Full-Text
Frailty and prognosis in lung cancer: systematic review and meta

© 2014-2025 likytut.eu. All rights reserved.