IJMS, Free Full-Text
Por um escritor misterioso
Last updated 22 março 2025

Our recent study demonstrated that the CC-chemokine ligand 2 (CCL2) present in primary afferent fibers (PAFs) plays an important role in the microglia-dependent neuronal activation associated with zymosan-induced inflammatory pain. The present study was aimed to evaluate whether BD1047 (a prototypical sigma-1 receptor (Sig-1R) antagonist) is capable of modifying elevated levels of inflammation-evoked CCL2 as a peripheral antinociceptive mechanism. In DRG primary culture, zymosan dose-dependently increased CCL2 release from isolectin B4 (IB4)-positive DRG neurons, a process that was inhibited by co-culture with BD1047. Single treatment of BD1047 before intraplantar injection of zymosan in rats significantly reduced thermal hyperalgesia and mechanical hyperalgesia, as well as CCL2 expression in DRG neurons and microglia activation in the spinal dorsal horn. In the Complete Freund’s adjuvant (CFA)-induced inflammation model, repeated administration of BD1047 dramatically attenuated thermal hyperalgesia and mechanical hyperalgesia, and significantly diminished CCL2 immunoreactivity and microglia activation. Notably, CFA-induced inflammation significantly increased Sig-1R immunoreactivity in DRG neurons, which was co-localized with CCL2 and IB4, respectively. Taken together, our results suggest that BD1047′s anti-nociceptive property was substantially mediated by the inhibition of CCL2 release in unmyelinated PAFs and that this may, in turn, have attenuated the spinal microglia activation that is associated with inflammatory pain.

IJMS, Free Full-Text

IJMS, Free Full-Text
Cleverativity on LinkedIn: IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS, Free Full-Text
Fair Priced FavoriteIJMS, Free Full-Text, louis velasquez cgm

IJMS, Free Full-Text

Ijms Free Full Text Neural And Hormonal Basis Of 49680

IJMS, Free Full-Text
Recomendado para você
-
New additions to my collection : r/MondoGore22 março 2025
-
Disturbing Movies Iceberg - Page 222 março 2025
-
Nomes dos Clips do Most Disturbed Person On Planet Earth 1 #mdpope22 março 2025
-
The Waiting Shed on X: Most Disturbed Person on Planet Earth I and II This tweet is a marker that I'm finally done with the second one (over 3 hours long). Mostly22 março 2025
-
Most Disturbed Person On Planet Earth 2 - Trakt22 março 2025
-
THIS IS ME BREATHING - M.D.P.O.P.E [OFFICIAL VISUALIZER] (2023) SW EXCLUSIVE22 março 2025
-
EXHUMATION by MDPOPE on Music Unlimited22 março 2025
-
Forests, Free Full-Text22 março 2025
-
Tule elk selection of surface water and forage is mediated by season and drought – California Fish and Wildlife Scientific Journal22 março 2025
-
ACP - Hygroscopic behavior of aerosols generated from solutions of 3-methyl-1,2,3-butanetricarboxylic acid, its sodium salts, and its mixtures with NaCl22 março 2025
você pode gostar
-
SonAmy Snuggle by Dani, Sonic the Hedgehog22 março 2025
-
Berlim: Netflix confirma data de estreia de spin-off de 'La Casa de Papel' - Metropolitana FM22 março 2025
-
Kage no Jitsuryokusha ni Naritakute!' Unveils Main Staff for 202222 março 2025
-
Easiest way to make coins on the web app ??? : r/fut22 março 2025
-
CLASSROOM OF THE ELITE 1 TEMPORADA DUBLADO DATA DE LANÇAMENTO22 março 2025
-
Live – Proteção Social Cultura de Resistência: O Estatuto da22 março 2025
-
Jogo Assassin's Creed Mirage Ps4 Midia Fisica PT BR Original - Ubisoft - Jogos de Ação - Magazine Luiza22 março 2025
-
Argentina 3 (4) x (2) 3 França: Assista aos gols e aos melhores22 março 2025
-
Metaverso e a inserção digital, Multiverso22 março 2025
-
Penalty Shootout - Golden Boot Java Game - Download for free on PHONEKY22 março 2025