IJMS, Free Full-Text
Por um escritor misterioso
Last updated 14 março 2025

Our recent study demonstrated that the CC-chemokine ligand 2 (CCL2) present in primary afferent fibers (PAFs) plays an important role in the microglia-dependent neuronal activation associated with zymosan-induced inflammatory pain. The present study was aimed to evaluate whether BD1047 (a prototypical sigma-1 receptor (Sig-1R) antagonist) is capable of modifying elevated levels of inflammation-evoked CCL2 as a peripheral antinociceptive mechanism. In DRG primary culture, zymosan dose-dependently increased CCL2 release from isolectin B4 (IB4)-positive DRG neurons, a process that was inhibited by co-culture with BD1047. Single treatment of BD1047 before intraplantar injection of zymosan in rats significantly reduced thermal hyperalgesia and mechanical hyperalgesia, as well as CCL2 expression in DRG neurons and microglia activation in the spinal dorsal horn. In the Complete Freund’s adjuvant (CFA)-induced inflammation model, repeated administration of BD1047 dramatically attenuated thermal hyperalgesia and mechanical hyperalgesia, and significantly diminished CCL2 immunoreactivity and microglia activation. Notably, CFA-induced inflammation significantly increased Sig-1R immunoreactivity in DRG neurons, which was co-localized with CCL2 and IB4, respectively. Taken together, our results suggest that BD1047′s anti-nociceptive property was substantially mediated by the inhibition of CCL2 release in unmyelinated PAFs and that this may, in turn, have attenuated the spinal microglia activation that is associated with inflammatory pain.

IJMS, Free Full-Text

IJMS, Free Full-Text
Cleverativity on LinkedIn: IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS, Free Full-Text
Fair Priced FavoriteIJMS, Free Full-Text, louis velasquez cgm

IJMS, Free Full-Text

Ijms Free Full Text Neural And Hormonal Basis Of 49680

IJMS, Free Full-Text
Recomendado para você
-
Frontiers Soil toposequences, soil erosion, and ancient Maya14 março 2025
-
What is mdpope 1 3|TikTok Search14 março 2025
-
บ่อน้ำของซามาร่า - ****** #อันดับ1 : ไตรภาคหนังในตระกูล “เอ็มดี-ป๊อป-อี” MDPOPE (Most Disturbed Person On Planet Earth / 2013-2014-2019) หนังมหาประลัยจากนรกโลกันต์-หนังอันตรายที่สุดในโลก! เป็นน้องใหม่สดๆซิงๆเมื่อปีที่เเล้วก็จริง เเต่ขอบอกว่าโหดจัดเพราะ14 março 2025
-
MDDOPE Trailer 1 Upcoming EDM Gore Album14 março 2025
-
Disturbing Movies Iceberg - Page 214 março 2025
-
Forests, Free Full-Text14 março 2025
-
Chemokine Receptors in Allergy, Inflammation, and Infectious Disease14 março 2025
-
Importance of Hydroxyl Radical Chemistry in Isoprene Suppression of Particle Formation from α-Pinene Ozonolysis14 março 2025
-
Most Disturbed Person On Planet Earth MDPOPE 1 Movie Re-Review : r/SummrsXo14 março 2025
-
MDPOPE 5 (2021) : Free Download, Borrow, and Streaming : Internet Archive14 março 2025
você pode gostar
-
🔥 Download Sushi Inc 1.4.25 [Mod Money/Adfree] APK MOD14 março 2025
-
Microsoft 365 Services – When and Why to Use Them - TPG The Project Group14 março 2025
-
Read Soredemo Ayumu Wa Yosetekuru Chapter 220: The 220Th Move on14 março 2025
-
Bebe reborn realista silicone mole14 março 2025
-
CONTA LEVEL 2173 COM A MELHOR E MAIS - Roblox - Blox Fruits - GGMAX14 março 2025
-
Robinhood's plan to “democratize finance” hit a GameStop-shaped speed bump [Updated]14 março 2025
-
Galaxy Tips: How to copy & paste across devices14 março 2025
-
Mommy Long Legs Costume Fancy Dress. Face Swap. Insert Your Face ID:85593314 março 2025
-
Rikki-Tikki-Tavi (Illustrated) - Kindle edition by Kipling14 março 2025
-
Stream ASSISTIR! Homem-Aranha: Através do Aranhaverso (2023) Filme Dublado Completo Gratis by stfu14 março 2025