IJMS, Free Full-Text
Por um escritor misterioso
Last updated 14 março 2025

Niemann–Pick type C (NPC) disease is an autosomal recessive storage disorder, characterized by abnormal sequestration of unesterified cholesterol in the late endo-lysosomal system of cells. Progressive neurological deterioration and the onset of symptoms, such as ataxia, seizures, cognitive decline, and severe dementia, are pathognomonic features of the disease. In addition, different pathological similarities, including degeneration of hippocampal and cortical neurons, hyperphosphorylated tau, and neurofibrillary tangle formation, have been identified between NPC disease and other neurodegenerative pathologies. However, the underlying pathophysiological mechanisms are not yet well understood, and even a real cure to counteract neurodegeneration has not been identified. Therefore, the combination of current pharmacological therapies, represented by miglustat and cyclodextrin, and non-pharmacological approaches, such as physical exercise and appropriate diet, could represent a strategy to improve the quality of life of NPC patients. Based on this evidence, in our review we focused on the neurodegenerative aspects of NPC disease, summarizing the current knowledge on the molecular and biochemical mechanisms responsible for cognitive impairment, and suggesting physical exercise and nutritional treatments as additional non-pharmacologic approaches to reduce the progression and neurodegenerative course of NPC disease.

IJMS Free Full Text Cell Adhesion And Its Endocytic Regulation InSexiezPicz Web Porn

IJMS, Free Full-Text

Fair Priced FavoriteIJMS, Free Full-Text, louis velasquez cgm

Ijms Free Full Text Abnormalities In Alternative 25056

IJMS, Free Full-Text

IJMS, Free Full-Text

Fair Priced FavoriteIJMS, Free Full-Text, louis velasquez cgm

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS, Free Full-Text
Recomendado para você
-
Niemann-Pick Type C « Niemann-Pick Children's Fund, Inc14 março 2025
-
PDF] Oxidative Stress: A Pathogenic Mechanism for Niemann-Pick Type C Disease14 março 2025
-
Niemann Pick Disease - an overview14 março 2025
-
National Niemann-Pick Disease Foundation, Inc. - October is14 março 2025
-
List Niemann-Pick as rare disease, parents of young patients urge14 março 2025
-
Niemann–Pick disease14 março 2025
-
Recommendations on the diagnosis and management of Niemann-Pick14 março 2025
-
Bone marrow involvement in Niemann Pick disease - 1.14 março 2025
-
Niemann-Pick Disease - A Bibliography by Parker, Philip M.14 março 2025
-
Baby With Niemann-Pick Disease — Marian McGlocklin Story14 março 2025
você pode gostar
-
cat matching pfp Cat icon, Cute icons, Cute anime profile pictures14 março 2025
-
Marcos Correa on X: #HGLG11: Um dos nossos maiores14 março 2025
-
Quebra Cabeça Pista Para Carrinhos HW Escala 1:64 Em Mdf14 março 2025
-
Baixe Play Séries, Filmes e Animes no PC com MEmu14 março 2025
-
Angels pitcher Tyler Skaggs dead at 27; found in hotel room14 março 2025
-
Riddle School 🕹️ Play on CrazyGames14 março 2025
-
This Oaxacan Beach Town Is a Surfer's Paradise — and It's on the Rise Among Digital Nomads14 março 2025
-
well uhm idk what to do ok #fyp #viral #foryou14 março 2025
-
Leadale no Daichi nite (In the Land of Leadale) · AniList14 março 2025
-
11 New Team Building Games in 202114 março 2025