IJMS, Free Full-Text
Por um escritor misterioso
Last updated 24 março 2025

Biomedical research aims to understand the molecular mechanisms causing human diseases and to develop curative therapies. So far, these goals have been achieved for a small fraction of diseases, limiting factors being the availability, validity, and use of experimental models. Niemann–Pick type C (NPC) is a prime example for a disease that lacks a curative therapy despite substantial breakthroughs. This rare, fatal, and autosomal-recessive disorder is caused by defects in NPC1 or NPC2. These ubiquitously expressed proteins help cholesterol exit from the endosomal–lysosomal system. The dysfunction of either causes an aberrant accumulation of lipids with patients presenting a large range of disease onset, neurovisceral symptoms, and life span. Here, we note general aspects of experimental models, we describe the line-up used for NPC-related research and therapy development, and we provide an outlook on future topics.

IJMS, Free Full-Text
Ijms Free Full Text Hyaluronic Acid Influence On Normal And Osteoarthritic Tissue Engineered

IJMS, Free Full-Text

IJMS, Free Full-Text

non sense codon –

IJMS, Free Full-Text

IJMS Free Full-Text Immunoglobulin Abnormalities In Gaucher, 48% OFF

IJMS, Free Full-Text

IJMS, Free Full-Text
Recomendado para você
-
IJMS, Free Full-Text24 março 2025
-
A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered24 março 2025
-
Niemann-Pick disease type C as a neurovisceral disease. Schematic24 março 2025
-
Potential treatment for Niemann-Pick type C, a rare neurodegenerative disease24 março 2025
-
Niemann–Pick type C disease: cellular pathology and pharmacotherapy - Wheeler - 2020 - Journal of Neurochemistry - Wiley Online Library24 março 2025
-
A hopeful therapy for Niemann-Pick C diseases - The Lancet24 março 2025
-
Searching for a cure for Niemann-Pick Type C - NemaMetrix24 março 2025
-
IJMS, Free Full-Text24 março 2025
-
TRIALS: A Fight for Children with Niemann-Pick Type C, a Fatal Genetic Disease24 março 2025
-
G1 - Doença rara em menina de 2 anos mobiliza campanha de família no RS - notícias em Rio Grande do Sul24 março 2025
você pode gostar
-
Project - Infisical24 março 2025
-
The Golden Light of Dawn (Manhwa) –24 março 2025
-
Hollywood: ¿Chloe Grace Moretz tiene un romance con Neymar? (FOTO)24 março 2025
-
Pastores com distintivo promovem reformas policiais24 março 2025
-
Blood Lad24 março 2025
-
Head Soccer 2023 - Enjoy4fun24 março 2025
-
Playbex Betting Solution posted on LinkedIn24 março 2025
-
Jogo Dino Hunter: Killing Strand no Jogos 36024 março 2025
-
FABIANO CARUANA + STOCKFISH 13 vs VACHIER LAGRAVE, Ronda 824 março 2025
-
25 anos de Yu Yu Hakusho no Brasil e as memórias de um pré-adolescente – Blog Daileon24 março 2025