Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals

Por um escritor misterioso
Last updated 03 novembro 2024
Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by  Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals
Sporadic amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects particularly motoneurons. Several pieces of evidence suggested the involvement of autoimmune mechanisms mediated by antibodies in ALS. However, the significance of those antibodies in the disease and the underlying mechanisms are unknown. Here we showed that IgG purified from a group of sporadic ALS patients, but not familial ALS patients, specifically interact with the presynaptic membrane of motoneurons through an antigen–antibody interaction and modulated synaptic transmission. Immunoreactivity against nerve terminals showed strong correlation with synaptic modulation ability. In addition, several controls have ruled out the possibility for this synaptic modulation to be mediated through proteases or nonspecific effects. Effective IgG potentiated both spontaneous and asynchronous transmitter release. Application of pharmacological inhibitors suggested that activation of this increased release required a nonconstitutive Ca2+ influx through N-type (Cav2.2) channels and phospholipase C activity and that activation of IP3 and ryanodine receptors were necessary to both activate and sustain the increased release. Consistent with the notion that ALS is heterogeneous disorder, our results reveal that, in ∼50% of ALS patients, motor nerve terminals constitutes a target for autoimmune response.
Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by  Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals
Calcium Signaling Pathways Mediating Synaptic Potentiation
Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by  Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals
Activity-dependent endoplasmic reticulum Ca2+ uptake depends on
Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by  Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals
Frontiers Dysregulation of Neuronal Calcium Signaling via Store
Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by  Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals
IJMS, Free Full-Text
Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by  Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals
Frontiers Microglia in Alzheimer's disease: pathogenesis
Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by  Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals
Primary Cultures of Rat Astrocytes and Microglia and Their Use in
Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by  Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals
IJMS, Free Full-Text
Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by  Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals
Calcium Signaling Pathways Mediating Synaptic Potentiation
Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by  Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals
The Neuroinflammation in the Physiopathology of Amyotrophic
Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by  Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals
Molecular pathways of motor neuron injury in amyotrophic lateral
Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by  Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals
Autoimmune synaptopathies Nature Reviews Neuroscience

© 2014-2024 likytut.eu. All rights reserved.