Replicatively senescent cells are arrested in G1 and G2 phases - Figure F1

Senescent human fibroblast cultures contain a large fraction of putative G2-arrested cells with 4N DNA content. (A) Propidium iodide (PI) staining and flow cyctometric analysis of HCA2 normal human foreskin fibroblasts. Cells entered senescence at PD73. (B) PI staining of replicatively senescent human lung fibroblasts WI-38, and IMR-90 at PDs 73 and 68 respectively. (C) The fraction of 4N cells in senescent cell population does not diminish with time. Replicatively senescent HCA2 cells were analyzed by PI staining at weekly intervals for 10 weeks stating from the onset of senescence.

JNK-dependent cell cycle stalling in G2 promotes survival and

Cellular Senescence: From Mechanisms to Current Biomarkers and

Transcriptional Regulation of the p16 Tumor Suppressor Gene

Full article: Senescence from G2 arrest, revisited

The molecular architecture of cell cycle arrest

Cellular senescence preserves viral genome maintenance

Full article: Dysregulated endolysosomal trafficking in cells

Proteostasis collapse halts G1 progression and delimits

Figures and data in Time-resolved single-cell sequencing

Reduced transcriptional activity in the p53 pathway of senescent

Quantitative profiling of adaptation to cyclin E overproduction

Key elements of cellular senescence involve transcriptional

Reorganization of chromosome architecture in replicative cellular

Single-cell transcriptomic analysis uncovers diverse and dynamic