The Safety of High Dose Labetalol in the Pregnant Population

Hypertension in pregnancy is one of the leading causes of maternal mortality and rapid treatment is critical. Treatment of emergent hypertensive crises in pregnancy is limited to only three medications, one of which is labetalol. Current literature recommends a daily maximum intravenous labetalol dose of 300 mg per day. However, this maximum dose has not been studied in pregnancy where higher doses may be required.

The vital signs and the cumulative labetalol dose over time. MAP = mean

Pharmacokinetics of the most commonly used antihypertensive drugs throughout pregnancy methyldopa, labetalol, and nifedipine: a systematic review

Labetalol and asthma: Possible risks, and complications

Dose required to achieve target blood pressure.

Hypertension Canada's 2018 Guidelines for the Management of Hypertension in Pregnancy - Canadian Journal of Cardiology

PDF) Safety and efficacy of methyldopa and labetalol in controlling blood pressure in hypertensive disorders of pregnancy

PDF) Oral nifedipine versus intravenous labetalol for severe hypertension during pregnancy: A systematic review and meta-analysis

LABETALOL HYDROCHLORIDE tablet, film coated

Frontiers Pregnancy-Related Hormones Increase UGT1A1-Mediated Labetalol Metabolism in Human Hepatocytes

Guideline No. 426: Hypertensive Disorders of Pregnancy: Diagnosis, Prediction, Prevention, and Management - Journal of Obstetrics and Gynaecology Canada

Relias Media

Trial of Intrapartum Extended-Release Nifedipine to Prevent Severe Hypertension Among Pregnant Individuals With Preeclampsia With Severe Features