Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet
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Last updated 16 fevereiro 2025
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://www.thelancet.com/cms/asset/15d778fc-530e-49dc-a599-cb2a6893daf3/gr1.gif)
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://www.thelancet.com/cms/attachment/3c6517d8-e343-478c-bfba-1aec3d1b81a8/gr1_lrg.jpg)
Safety of the oral factor XIa inhibitor asundexian compared with
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://www.tandfonline.com/action/showGraphicalAbstractImage?doi=10.1080%2F14779072.2023.2160319&id=ierk_a_2160319_uf0001_oc.jpg)
Full article: Atrial fibrillation and stroke
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://cdn.muni.cz/media/3445671/1-s20-s0140673622015884-gr1.gif?mode=crop¢er=0.5,0.5&rnd=133072079960000000&upscale=false&width=1200)
Factor XIa inhibition with asundexian after acute non
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://assets.radcliffecardiology.com/s3fs-public/video/2022-08/DELV_10061_IND_ESC_Shoamanesh_1920x1080%20%282%29.png?VersionId=1xZCLNAZkcz1kVksf_F.kxe3ypus3FQ6)
ESC 22: Dosing of Asundexian in Pts With Non-Cardioembolic
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://media.springernature.com/m685/springer-static/image/art%3A10.1007%2Fs13318-023-00838-4/MediaObjects/13318_2023_838_Fig2_HTML.png)
Metabolism and Disposition of the Novel Oral Factor XIa Inhibitor
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://www.ahajournals.org/cms/asset/569b1110-197f-45be-9746-f9518efa0506/circulationaha.122.061612.fig03.jpg)
A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://ars.els-cdn.com/content/image/1-s2.0-S1052305722004360-gr3.jpg)
Rationale and design of the AXIOMATIC-SSP phase II trial
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://journals.sagepub.com/cms/10.1177/1358863X231206778/asset/images/large/10.1177_1358863x231206778-fig1.jpeg)
Factor XI/XIa inhibitors for the prevention and treatment of
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://www.researchgate.net/publication/335845815/figure/tbl1/AS:927706938081282@1598193978991/Baseline-Characteristics-According-to-Treatment-Group-in-Participants-With-Ischemic-or.png)
Baseline Characteristics According to Treatment Group in
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://cdn.muni.cz/media/3445671/1-s20-s0140673622015884-gr1.gif?mode=crop¢er=0.5,0.5&rnd=133072079960000000&width=575)
Factor XIa inhibition with asundexian after acute non
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://ars.els-cdn.com/content/image/1-s2.0-S0735109723063921-ga1.jpg)
Antithrombotic Therapy for Primary and Secondary Prevention of
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://www.mdpi.com/pharmaceuticals/pharmaceuticals-16-00866/article_deploy/html/images/pharmaceuticals-16-00866-g003-550.jpg)
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