GPC2-CAR T cells tuned for low antigen density mediate potent

Pediatric cancers often mimic fetal tissues and express proteins normally silenced postnatally that could serve as immune targets. We developed T cell…

Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors

Cancers, Free Full-Text

GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity - ScienceDirect

Reprogramming T cell differentiation and exhaustion in CAR-T cell therapy, Journal of Hematology & Oncology

Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors

Membrane Proteome Array (MPA), Antibody Specificity Profiling

IOYIF on X: The #IOYIF21 Research Scientist Distinguished Young Investigator Award winner is Dr. @Heitzeneder_S for her work studying GPC2-CAR T-cells in neuroblastoma. Amazing work, Dr. Heitzeneder! @StanfordMed @StanfordCancer

Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting

Frontiers Fine-tuning the antigen sensitivity of CAR T cells: emerging strategies and current challenges

GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity - ScienceDirect

Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors. - Abstract - Europe PMC

Present Status and Advances in Chimeric Antigen Receptor T Cell Therapy for Glioblastoma

PDF) Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma

JCM, Free Full-Text