Assessment of neuroendocrine dysfunction following traumatic brain injury.

A screening protocol adapted for selected patients at risk for endocrine problems is described, and physicians should be aware of the importance of neuroendocrine dysfunction following TBI. Posttraumatic neuroendocrine pathology may be a clinically significant complication following traumatic brain injury TBI. Metabolic abnormalities are described after TBI in two cases. A 21 year old male injured in a motor vehicle accident admitted in a minimally responsive condition presented with fluctuating high sodium levels, undetectable serum testosterone, and depressed cortisol and thyroid function. Imaging revealed near complete avulsion of the pituitary stalk leading to panhypopituitarism. A 38 year old male admitted for occipital skull fractures and brain contusions presented with hypona tremia and low serum testosterone. Both patients required hormonal replacement and correction of electrolyte abnormalities. A screening protocol adapted for selected patients at risk for endocrine problems is described. While neuroendocrine screening is not advocated in all TBI patients, physicians should be aware of the importance of neuroendocrine dysfunction following TBI.

Clocks & Sleep, Free Full-Text

Frontiers Traumatic Brain Injury as Frequent Cause of Hypopituitarism and Growth Hormone Deficiency: Epidemiology, Diagnosis, and Treatment

JCM, Free Full-Text

Traumatic brain injury as a chronic disease: insights from the United States Traumatic Brain Injury Model Systems Research Program - The Lancet Neurology

Frontiers Traumatic Brain Injury as Frequent Cause of Hypopituitarism and Growth Hormone Deficiency: Epidemiology, Diagnosis, and Treatment

Traumatic brain injury: progress and challenges in prevention, clinical care, and research - The Lancet Neurology

Manual of Traumatic Brain Injury, Third Edition

Biomedicines, Free Full-Text

Assessment of neuroendocrine dysfunction following traumatic brain injury.

Neuroendocrine Testing and Therapy

Progress Toward a Multiomic Understanding of Traumatic Brain Injury: A Review - Philip A Kocheril, Shepard C Moore, Kiersten D Lenz, Harshini Mukundan, Laura M Lilley, 2022

How a Brain Injury Can Cause Hormone Dysregulation

Frontiers Mood Disorders in Young People With Acquired Brain Injury: An Integrated Model

Autonomic dysfunction following traumatic brain injury: translational insights in: Neurosurgical Focus Volume 47 Issue 5 (2019) Journals

Pituitary dysfunction after traumatic brain injury in children: is there a need for ongoing endocrine assessment? - Casano‐Sancho - 2013 - Clinical Endocrinology - Wiley Online Library